Immunoglobulin D(IgD):
IgD was first discovered when a patient developed a multiple myeloma protein failed to react with anti-isotype antisera against the then-known isotypes:IgA,IgM,and IgG.When rabbits were immunized with this myeloma protein,the resulting antisera were used used to identify the same class of antibody at low levels in normal human serum.
The new class,called IgD,has a serum concentration of 30 mu d/ml and constitute about 0.2% of the total immunoglobulin in serum.IgD,together with IgM,is the major membrane-bound immunoglobulin expressed by mature B cells,and its role in the physiology of B cells is under investigation.No biological effector function has been identified for IgD.
IgD was first discovered when a patient developed a multiple myeloma protein failed to react with anti-isotype antisera against the then-known isotypes:IgA,IgM,and IgG.When rabbits were immunized with this myeloma protein,the resulting antisera were used used to identify the same class of antibody at low levels in normal human serum.
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