Powered by Blogger.


Trying to provide all necessary information about IMMUNITY and IMMUNE SYSTEM

Antigen-Antibody Interactions|Immune system|Immunity or Immunology.

Posted by Mumtaz khan Monday, 27 February 2012

Antigen-Antibody Interactions: Strength or Antigen-Antibody Interactions.
         The noncovalent interactions that form the basis of antigen-antibody(Ag-Ab)binding include hydrogen bonds,ionic bonds,hydrophobic interactions,and van der waals interactions.Because these interactions are individually weak(compared with a covalent bond),a large number of such interactions are required to form a strong Ag-Ab interactions.Furthermore,each of these noncovalent interactions operates over a very short distance,generally about 1 angstorms;consequently,a strong Ag-Ab interaction depends on a very close fit between the antigen and antibody.Such fits require a high degree of complementarity between antigen and antibody,a requirement that underlies the exquisite specificity that characterizes antigen-antibody interactions.

Antibody Affinity Is a Quantitative Measure of Binding Strength.
        The combined strength of a noncovalent interactions between a single antigen-binding site on an antibody and a single epitope is the affinity of the antibody for that epitope.Low-affinity of the antibodies bind antigen weakly and tend to dissociate readily,whereas high-affinity antibodies bind antigen more tightly and remain bound longer.The association between a binding site on an antibody(Ab)with a monovalent antigen(Ag)can be described by the equation.
Ag + Ab--------> Ag-Ab


1 Responses to Antigen-Antibody Interactions|Immune system|Immunity or Immunology.

  1. Creative Enzymes has been active in the enzyme industry for several years. In addition to conventional enzymatic techniques, we are also dedicated to development of emerging new sciences. abzymes


Post a Comment

About Me